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The role of reactive oxygen species in homeostasis and degradation of cartilage

Fluorescence spectra were acquired using an FS5 spectrofluorometer (Edinburgh Instruments) equipped with an SC-40 plate reader and 96-well plates (Corning) using Fluoracle software

Phenytoin-initiated DNA oxidation in murine embryo culture, and embryo protection by the antioxidative enzymes superoxide dismutase and catalase: evidence for reactive oxygen species-mediated DNA oxidation in the molecular mechanism of phenytoin teratogenicity